BDBM13530 4-[(4-methylpiperazin-1-yl)methyl]-N-[4-methyl-3-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide::CHEMBL941::Gleevec::Imatinib::Imatinib, 21::N-(4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide::STI-571::STI571::US10906896, Cpd imatinib::US11649218, Example Imatinib::US11725005, Compound imatinib::US9255107, Imatinib::cid_5291::imatinib-CD3::med.21724, Compound 6
SMILES CN1CCN(Cc2ccc(cc2)C(=O)Nc2ccc(C)c(Nc3nccc(n3)-c3cccnc3)c2)CC1
InChI Key InChIKey=KTUFNOKKBVMGRW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 88 hits for monomerid = 13530
3D Structure (crystal)Affinity DataKi: 13nMAssay Description:Inhibition of human recombinant Abl by filter-binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 13nMAssay Description:Inhibition of human recombinant c-Abl by filter-binding assayMore data for this Ligand-Target Pair
Affinity DataKi: 37nMAssay Description:Inhibition of unphosporylated AblMore data for this Ligand-Target Pair
Affinity DataKi: 7.00E+3nMAssay Description:Inhibition of phosporylated AblMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of human wild-type ABL (Ser229 to Gln513)-mediated phosphorylation of biotinylated poly-Glu-Tyr expressed in Escherichia coli BL21(DE3) pr...More data for this Ligand-Target Pair
Affinity DataKd: 77nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 35nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 8.5nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
Affinity DataIC50: 372nM EC50: 70nMAssay Description:CAII assays were performed at CEREP (paris). All other kinase assays were performed at Upstate (Dundee, UK).More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMpH: 7.4 T: 2°CAssay Description:Inhibition of wild-type Abl and Abl T315I kinase activity was measured in a homogeneous time-resolved fluorescence resonance energy transfer (TR-FRET...More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:In vitro kinase assay using human aurora kinase in a standard radiometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 8.60E+3nMAssay Description:In vitro kinase assay using human aurora kinase in a standard radiometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 3.10E+3nMAssay Description:In vitro kinase assay using human aurora kinase in a standard radiometric assay.More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of recombinant Abl kinase (unknown origin) expressed in Sf9 cells using GGEAIYAAPFKK as substrate in presence of [gamma33P]ATPMore data for this Ligand-Target Pair
Affinity DataKd: 2.20nMAssay Description:Average Binding Constant for ABL1 ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 14nMAssay Description:Average Binding Constant for ABL1(M351T) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Average Binding Constant for ABL1(Y253F); NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 6.20E+3nMAssay Description:Average Binding Constant for ABL1(T315I) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 62nMAssay Description:Average Binding Constant for ABL1(H396P) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Average Binding Constant for ABL1(E255K) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 188nMAssay Description:Inhibition of Abl kinaseMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding constant for ABL1-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 5.90nMAssay Description:Binding constant for ABL1(H396P)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.10nMAssay Description:Binding constant for ABL1-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 92nMAssay Description:Binding constant for ABL1(Q252H)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 65nMAssay Description:Binding constant for ABL1(H396P)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 2.5nMAssay Description:Binding constant for ABL1(F317L)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 580nMAssay Description:Binding constant for ABL1(F317I)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Binding constant for ABL1(M351T)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 170nMAssay Description:Binding constant for ABL1(E255K)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1(T315I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 130nMAssay Description:Binding constant for ABL1(Y253F)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 8.30nMAssay Description:Binding constant for ABL1(F317I)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 1.80nMAssay Description:Binding constant for ABL1(Q252H)-nonphosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 110nMAssay Description:Binding constant for ABL1(F317L)-phosphorylated kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: >1.00E+4nMAssay Description:Binding constant for ABL1(T315I) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 12nMAssay Description:Binding constant for ABL1 kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 21nMAssay Description:Binding constant for ABL1(Q252H) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 44nMAssay Description:Binding constant for ABL1(Y253F) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 77nMAssay Description:Binding constant for ABL1(E255K) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 35nMAssay Description:Binding constant for ABL1(H396P) kinase domainMore data for this Ligand-Target Pair
Affinity DataKd: 24nMAssay Description:Average Binding Constant for ABL1(Q252H) ; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of Abl (unknown origin) using GGEAIYAAPFKK peptide as substrate by [gamma-33P]ATP assayMore data for this Ligand-Target Pair
Affinity DataIC50: 98nMAssay Description:Inhibition of Abl (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of Abl (unknown origin)More data for this Ligand-Target Pair